PGT-SR is a form of embryo genetic testing designed for couples where one partner carries a structural rearrangement such as a balanced translocation or Robertsonian translocation.

What PGT-SR aims to do

It helps identify embryos less likely to be affected by:

  • unbalanced translocations,
  • segmental duplications/deletions,
  • and related chromosomal imbalances.

Who may benefit most

  • recurrent pregnancy loss with a known translocation
  • repeated IVF failure with a confirmed rearrangement
  • family history of structural chromosomal abnormalities

Important limitations

PGT-SR can improve embryo selection, but it does not guarantee pregnancy. Success also depends on:

  • maternal age and egg quality,
  • embryo development,
  • uterine factors and transfer strategy,
  • and lab performance.

FAQ

  • Is PGT-SR the same as PGT-A? No—PGT-A screens for aneuploidy; PGT-SR is tailored to structural rearrangements.
  • Do we still need prenatal testing? Often recommended depending on case and clinic policy.

CTA: If you carry a translocation, request a PGT-SR readiness review with our genetics team.