Chromosomal microarray (CMA) detects copy number variations (CNVs)—small deletions or duplications that may not be visible on standard karyotyping.
Where CMA is most useful
- evaluating products of conception after miscarriage (when available)
- investigating fetal anomalies found on ultrasound
- clarifying suspected unbalanced translocations
- checking for cryptic imbalances in “balanced” rearrangements (selected cases)
CMA vs karyotype
- Karyotype: best for large structural rearrangements (like balanced translocation).
- CMA: best for detecting gains/losses (duplications/deletions), but may not fully characterize balanced rearrangements.
How it fits into an IVF plan
CMA is often part of diagnostic workups and prenatal decisions rather than routine IVF testing, but it can inform whether PGT-SR or other strategies are appropriate.
FAQ
- Can CMA replace karyotype? Not always—each has strengths.
- Does CMA detect balanced translocations? Usually not; it detects copy number, not balanced exchanges.
CTA: Ask our team which test best matches your history: karyotype, CMA, or both.