FISH (fluorescence in situ hybridization) uses labeled DNA probes to look at specific chromosome regions. It is especially useful when clinicians need targeted confirmation.
Common indications
- confirming a suspected rearrangement seen on karyotype
- testing a specific family translocation in relatives
- clarifying complex rearrangements
- supporting breakpoint-region questions in selected scenarios
How it complements other tests
- Karyotype: broad view of chromosome structure
- CMA: detects gains/losses
- FISH: targeted confirmation of specific regions
FAQ
- Is FISH used for embryo testing? Many labs use different platforms for PGT; discuss methods with your IVF lab.
- Does FISH detect all abnormalities? No—it’s region-specific.
CTA: Ask whether FISH can answer your specific diagnostic question.