Repeated implantation failure can occur for several reasons, but genetics may play a key role when one partner carries a balanced translocation.

The genetic mechanism

Even if embryo morphology looks good, some embryos may carry segmental imbalances that reduce implantation potential. Balanced translocation can raise the proportion of embryos with such imbalances.

A targeted evaluation

A practical plan often includes:

  • confirming karyotype in both partners (if not done),
  • reviewing prior IVF outcomes and embryo development patterns,
  • considering PGT-SR if a structural rearrangement is found.

Building a transfer strategy

Once embryos are tested, clinicians can tailor:

  • transfer timing and preparation,
  • number of embryos to transfer (based on local regulations),
  • and follow-up pregnancy testing.

FAQ

  • Is implantation failure always genetic? No—uterine, hormonal, and immunologic factors can contribute too.
  • If we already did PGT-A, do we still need PGT-SR? PGT-A may not fully address structural rearrangements; discuss lab capability.

CTA: Ask about a genetics-first implantation failure evaluation.