A reciprocal translocation occurs when two non-homologous chromosomes exchange segments. If no DNA is gained or lost, the carrier is “balanced,” but reproduction can still be affected.
How it impacts embryos
During meiosis, chromosomes must pair and separate correctly. In reciprocal translocation carriers, this process can generate embryos with:
- segmental duplications,
- segmental deletions,
- or more complex imbalances.
When to suspect carrier status
- multiple miscarriages (especially early first-trimester losses)
- repeated IVF implantation failure
- family history of chromosomal rearrangements
- a child or pregnancy with a known chromosomal imbalance
IVF and PGT-SR
PGT-SR is specifically designed for structural rearrangements, helping identify embryos that are:
- chromosomally normal, or
- balanced like the carrier (depending on lab reporting policy and local regulations).
FAQ
- Is reciprocal translocation the same as Robertsonian? No—Robertsonian involves acrocentric chromosomes and fusion, not exchange.
- Does being a carrier mean we can’t have a healthy baby? Many carriers do—planning matters.
CTA: Request a reproductive genetics consult to review your karyotype and IVF strategy.